SLC5A1 and type 2 diabetes mellitus: Although SGLT1 has been found in several other organs, the lack of a clear understanding of the function of SGLT1 in these tissues, the effect of SGT1 inhibition on the microbiome, and the alteration of SGLT1 expression in various tissues on comorbidities, such as HF and T2D, suggest the need for further investigation of SGLT1 and SGLT1/2 inhibitors.