Recent studies have shown that there is a significantly increased number of Th17 cells, a higher concentration of IL-17A, and a larger number of IL-17A receptors in the orbital tissue of patients with GO, and relative amounts of inflammatory cytokines, such as IL-6 and IL-8, are also increased, promoting the accumulation of ECM in orbital fibroblasts [4]. Here, IL17RA is linked to geroderma osteodysplastica.