LONP1 and prostate adenocarcinoma: FUNDC1 is believed to play a role in stabilizing LONP1, as evidenced by observations of LONP1 misfolding in prostate adenocarcinoma cells upon loss of FUNDC1; recombinant LONP1 also fails to restore the reduced catalytic activity of LONP1, which suggests that FUNDC1 may promote LONP1 activity and thus facilitate the subsequent degradation of unfolded proteins [54].