NFE2L2 and Alzheimer disease: According to a molecular study, ashwagandha root helps in treating AD by preventing nuclear factor B activation, promoting nuclear factor erythroid 2-related factor 2 (Nrf2) migration to the nucleus, where it enhances the expression of antioxidant enzymes, to reduce the formation of amyloid, decrease apoptotic cell death, restore synaptic function, and boosts the immune system [199].