A total of 14 candidate hub genes most likely to mediate NASH and TNBC occurrence were identified, including TLR4, CYBB, NCF1, NCF2, S100A8, S100A9, ITGB2, RAC2, ITGAM, CYBA, ICAM1, CXCL10, CXCR3, and ITGAL. This evidence concerns the gene ITGB2 and metabolic dysfunction-associated steatohepatitis.