A total of 14 candidate hub genes most likely to mediate NASH and TNBC occurrence were identified, including TLR4, CYBB, NCF1, NCF2, S100A8, S100A9, ITGB2, RAC2, ITGAM, CYBA, ICAM1, CXCL10, CXCR3, and ITGAL. Here, TLR4 is linked to metabolic dysfunction-associated steatohepatitis.