- ↑ mitochondrial fission (↑ Drp1) [1,262,263,264]- ↑ mitophagy [1,262,263,264]- ↑ OXPHOS [1,262,263,264]The effect of tumor-suppressive therapy in RAS-driven tumors:- ┤Drp1 [262,263,264]- ↑ Mfn2 expression (mitochondrial fusion induced by doxycycline/leflunomide) [263]- ↓ autophagy proteins [265]. Here, DNM1L is linked to neoplasm.