PDK1 and cancer: In cardiac muscle cells [309] and in a cancer cell line [310], the FGFR1-like receptor was also detected in the mitochondria, where it activated pyruvate dehydrogenase (PDH) kinase 1 (PDHK1), resulting in PDH inhibition and reduced pyruvate-to-acetyl-CoA conversion and subsequently reduced glycolysis and an enhanced Wartburg effect [310].