ATM and neoplasm: Consequently, BRCA1 deficiency impairs stress-induced mitophagy by blocking ataxia-telangiectasia mutated (ATM)-AMP-activated protein kinase (AMPK) and dynamin-related protein 1 (Drp1)-mediated mitochondrial fission, triggering NLRP3 inflammasome activation and changing the microenvironment to facilitate tumor proliferation and metastasis [178].