Remarkably, a genomic marker of compromised mitophagy was described in the peripheral fluids of some patients with AD syndrome, as demonstrated by a lessening of the autophagic ATG5 aspect and Parkin amounts in the circulating blood of AD patients [61], and a decline of Parkin content against a rise in the mRNA of LC3 and PINK1 at early stages in circulating blood [32]. This evidence concerns the gene PRKN and Alzheimer disease.