PRKN and Alzheimer disease: There is great value in seeing that all mitophagy indicator differences related to APP-CTF aggregation, especially concerning pTau and Aβ in an amount only connected to amplified LC3-II/I proportions and decreased Parkin, respectively, indicate a greater relation of sequestration miscarriage in mitochondria with APP-CTF aggregation in the neurons of people with AD in the brain tissues [35].