PINK1 and Alzheimer disease: Previous investigations have examined the effects of PINK1 in a preclinical AD exemplary presentation and showed that intraneurons in brain tissue cause stereotaxic vaccinations of AAV2-hPINK1 in transgenic rats at six months, exhibiting an upregulation of hAPP comportment Indiana (V717F), and that Swedish mutations trigger the stimulation of mitophagy via an over-regulation of both NDP52 and OPTN mitophagy receptors [53].