Although studies in patients suffering from AD showed evidence supporting a contributing role of ICAM-1 and VCAM-1 in AD by proof of higher dermal vascular expressions of these two molecules, there has been evidence of adhesion molecule ICAM-1 in the endothelium, in cells surrounding blood vessels, and in the (supra)basal layer of the epidermis [19,20,24,28]. The gene discussed is VCAM1; the disease is Alzheimer disease.