NPPB and hydrops fetalis: All three assessed biomarkers were significant predictors for acute HF (Table 3); ROC analysis exhibited a consistent predictive value for syndecan-1, mirrored by its AUC of 0.898, showing a statistically significant performance (p < 0.05) in predicting acute HF, only slightly inferior to the gold-standard NTproBNP (AUC = 0.976) but substantially higher than that of hs-troponin (AUC = 0.838) (Figure 3).