There was a significantly increased frequency of carriers of the APOE ε4 allele but not the MMP2 rs243866 A allele (p < 0.0001), followed by carriers of both MMP2 rs243866 A and APOE ε4 alleles (p < 0.0001) in the AD group as compared to the controls. This evidence concerns the gene MMP2 and Alzheimer disease.