However, a subanalysis of PARADIGM-HF (Prospective Comparison of ARNI [Angiotensin Receptor–Neprilysin Inhibitor] with ACEI [Angiotensin-Converting Enzyme Inhibitor] to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial) found that patients with CAD had a higher crude incidence of mortality and readmissions; however, outcome did not differ by etiology (CAD, idiopathic, or hypertensive) when adjusting for other variables, such as age and comorbidity [8]. The gene discussed is ACE; the disease is coronary artery disorder.