WEE1 and metastatic melanoma: In one study, the high expression of Wee1 was related to the poorer survival of patients with malignant melanoma, and knocking out Wee1 caused DNA damage and apoptosis in WM239 (WTp53) and WM45.1 (MTp53) metastatic melanoma cell lines, suggesting Wee1 had a potential prognostic effect independent of p53 status [138].