CD274 and familial pancreatic carcinoma: In pancreatic cancer mouse xenograft models, the inhibition of Wee1 or Wee1 + ATM notably hindered tumor proliferation but downregulated the expression of several tumoral immune escape promoters (including PD-L1, CMTM6, CD163 and CXCR2), suggesting a complex link between DDRi and immune response in tumors, which should be elucidated in later research [175].