In the same trend, the current pattern of kidney disease detection benefits from the modern advancement in molecular analysis and identifies biomarkers for evaluating and characterizing kidney diseases; therefore, the most promising biomarkers with a strong foundation in the pathophysiology of kidney disease were found to be neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), TIMP-2, α1-Microglobulin, liver-type fatty acid-binding protein (L-FABP), uromodulin (UMOD), interleukin-18 (IL-18), TNF-α and IL-1β, P3NP, and epidermal growth factor (EGF) [19]. The gene discussed is TNF; the disease is kidney disorder.