In patients with valve involvement, female sex (83% vs. 64%; p = 0.013), arterial hypertension (47% vs. 29%; p = 0.025), arterial thrombosis at APS diagnosis (53% vs. 33%; p = 0.028), stroke (38% vs. 21%; p = 0.043), livedo reticularis (15% vs. 3%; p = 0.017), LAC (83% vs. 65%; p = 0.021), and double aPL positivity (61% vs. 39%; p = 0.045), were more prevalent than in patients without valve involvement. The gene discussed is FASLG; the disease is Hypertension.