It is worth mentioning that some molecules that have received extensive attention in cancer-related studies, such as the Bcl-2 family, caspase family, tumor necrosis factor-α (TNF-α), Parkin and phosphate and tension homology deleted on chromosome ten (PTEN) induced putative kinase 1 (PINK1), are closely related to the development and progression of PD. This evidence concerns the gene TNF and cancer.