SNCA and Parkinson disease: A neurodegenerative disorder involves the loss of neurons, impairment of synaptic plasticity, proteinopathies, and other abnormalities [5], which include misfolded amyloid-β and tau in Alzheimer’s disease, α-synuclein in Parkinson’s disease (PD) [6,7,8], as well as progressive muscle atrophy or muscle wasting.