POMC and Cowden syndrome 1: Population: ACTH-dependent CS Adenoma detection:- MRI: + in 20/24 (83%), − in 4/24 (17%; of which 1 empty sella, 2 normal and 1  post-op changes > CRH PET–CT  correctly delineated lesions)- 68Ga-DOTA-CRH PET–CT = + in 24/24  (100%), lateralization also 100%Histological confirmation.: yesOutcome: PET information used for intraoperative navigation: biochemical remission in 12/17 (71%) of micro- and 4/7 (57%) macroadenoma