Skov et al. proved that reduced levels of PGC-1α seemingly contribute to the downregulation of mitochondrial oxidative phosphorylation genes in PCOS [50], whereas Liu et al. investigated the effect of PGC-1α on granulosa cell injury and observed a significant decrease in the expression of PGC-1α, along with a significant upregulation of cell apoptosis and reactive oxygen species (ROS) generation in the obese PCOS patient group [51]. Here, PPARGC1A is linked to polycystic ovary syndrome.