Furthermore, Zhang et al. generated an insulin-resistant PCOS rat model and revealed significant PPARγ upregulation after myoinositol supplementation [102], whereas Safaei et al. examined the effect of vitamin D3 on mitochondrial biogenesis of granulosa cells in a PCOS-induced mouse model and outlined PGC-1a upregulation upon vitamin D3 administration [103]. This evidence concerns the gene INS and polycystic ovary syndrome.