PPARGC1A and polycystic ovary syndrome: However, Emidio et al. used a PCOS mouse model induced by the administration of dehydroepiandrosterone (DHEA) and reported low PGC-1α levels [45], while El-Saka et al. induced PCOS in female Wistar rats by letrozole and underlined the suppression of PPARγ pathways [46].