PPARG and Hirsutism: Moreover, Hahn et al. analyzed PPARγ alleles in 102 PCOS patients and 104 age-matched control women and concluded that the Pro12Ala polymorphism correlates with higher insulin sensitivity and decreased hirsutism scores in PCOS women [69], while Koika et al. suggested that the Pro12Ala polymorphism in the PPARγ2 gene correlates with reduced basic metabolic rate in patients with PCOS and laboratory hyperandrogenemia [70].