PPARG and polycystic ovary syndrome: In 2003, Orio et al. examined PPARγ polymorphisms at exons 2 and 6 in 100 PCOS women and suggested a higher frequency of the C to T substitution in exon 6 of obese PCOS patients, with the Pro12Ala polymorphism at exon 2, however, not affecting body mass index (BMI) in PCOS women [60].