Shaikh et al. investigated the associations of Pro12Ala and His447His PPARγ polymorphisms with PCOS susceptibility in an Indian population and concluded that the Pro12Ala polymorphism significantly correlates with diminished PCOS susceptibility, while both polymorphisms improve glucose metabolism by influencing 2 h glucose, fasting insulin, or insulin resistance [82]. This evidence concerns the gene INS and polycystic ovary syndrome.