Multiple factors associated with severe COVID-19 and its mortality have also been reported, such as age older than 65 years, male sex, pre-existing comorbidities (e.g., hypertension, diabetes, cardiovascular disease, and chronic kidney disease), laboratory indices (e.g., C-reactive protein, CRP; lactate dehydrogenase, LDH; procalcitonin; aspartate aminotransferase, AST; and alanine aminotransferase, ALT), and proinflammatory cytokines (e.g., Interleukin-6, IL-6; IL-8; IL-10; IL-2R; and tumor necrosis factor, TNF-α) [9,10,11]. This evidence concerns the gene TNF and hypertensive disorder.