The commonly used antidiabetic drugs metformin and resveratrol have also been found to protect the integrity of the mitochondria by inhibiting the activity of the DRP1 enzyme and preventing the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasomes (mediating activation of caspase-1 and proinflammatory cytokine secretion) via the suppression of endoplasmic reticulum-originated stress and portrayed beneficial effects by protecting the cellular functions under the state of hyperglycemia [55]. This evidence concerns the gene NLRP3 and Hyperglycemia.