VWF and thrombotic thrombocytopenic purpura: The classic example for this application is thrombotic thrombocytopenic purpura (TTP), a potentially fatal thrombotic microangiopathy (TMA), resulting from an acquired or inherited inefficacy of the von Willebrand factor cleaving protease ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) and subsequent disseminated thrombotic events [5].