These studies identify various genetic variants associated with increased risks of developing AMD, including a common single nucleotide polymorphism (SNP) in the CFH gene (CFH p.Y402H) conferring an approximately two-fold higher risk of developing late-stage AMD per allele [76] and a common haplotype affecting the age-related maculopathy susceptibility 2 (ARMS2) and HtrA serine peptidase 1 (HTRA1) gene loci [77]. This evidence concerns the gene HTRA1 and age-related macular degeneration.