Model 2: predictors of highest sST2 quartile adjusted for number of MACE, as well as age, gender, BMI, DM, hypertension, dyslipidemia, history of ischemic heart disease, heart failure, atrial fibrillation, and use of medications including statins, antiplatelets, beta-blockers, ACE inhibitors, ARBs and ARNI. This evidence concerns the gene ACE and heart failure.