Importantly, more of the recent studies demonstrated the prognostic value of sST2 in patients with diabetes: sST2, Hs-cTnI, and NT-proBNP are independently associated with mortality and onset of MACE in patients with diabetes; specifically, higher levels of sST2 led to an almost three-fold increase in the risk of death in a 15 year follow-up [32]. This evidence concerns the gene TNNI3 and diabetes mellitus.