Model 1: predictors for any unplanned MACE admissions adjusted for age, gender, BMI, hypertension, dyslipidemia, history of ischemic heart disease, heart failure, diabetes mellitus (DM), atrial fibrillation, and use of medications including statins, antiplatelets, beta-blockers, ACE inhibitors, ARBs, and ARNI. This evidence concerns the gene ACE and heart failure.