Atopic disorders include various lung inflammatory diseases (e.g., allergic asthma and IgE-mediated components of allergic aspergillosis), allergic rhinitis, conjunctivitis, and atopic dermatitis, in which metabolic abnormalities of the leukotriene pathway play a crucial role [11,12,13,14,15,16,17,18]. Here, IGHE is linked to atopic eczema.