The aim of this work was to study the levels of MMPs and HSPs on the surfaces of CD9- and FABP4-positive plasma sEVs in CRC patients (CRCPs) in relation to metabolic status with markers of angiogenesis in the primary tumor, as well as to evaluate markers in sEVs as predictors of the effectiveness of thermoradiotherapy. Here, CD9 is linked to colorectal carcinoma.