In CRC, compared with CP, the proportion of triple-positive sEVs and sEVs with the MMP9+MMP2-TIMP1+ phenotype increased significantly among FABP4-positive sEVs, which, in general, may indicate the overexpression of MMP9 and TIMP1 by adipocytes or adipose tissue macrophages in CRCPs. Here, TIMP1 is linked to colorectal carcinoma.