Although Western blotting was used to determine the level of HSPs in exosomes in [27] and flow cytometry was used in our work, we obtained similar data on the distribution of HSPs in sEVs of patients with pre-tumor disease and CRC, indicating the predominance of HSP60 and HSP27 on of both CD9-positive sEVs and FABP4-positive sEVs. Here, CD9 is linked to neoplasm.