PIK3CA and cancer: Combining with other oncogenes, activating PIK3CA mutations in transgenic mice were utilized to create various types of cancer mouse models (such as colon, prostate, lung, and brain cancers, etc.)[163,164,165,166,167,168,169,170], in either a non-inducible [96,125,171] or conditional and inducible system [79,95,132,163,167].