Since most common GOF PIK3CA mutations (hotspots) in breast cancers are somatic point mutations, by utilizing the GDC data portal from the National Cancer Institute (NCI), simple somatic mutations (SSM) of breast cancer lesions for TP53 and PIK3CA genes, along with all key CmPn signaling components, were assessed with Oncogrid. This evidence concerns the gene PIK3CA and breast cancer.