CSF3 and Ewing sarcoma: Increasing the dose of the agents did not improve the outcome [3]; however, giving interval-compressed (ic-) chemotherapy with VDC/IE scheduled every 14 days with the use of granulocyte colony stimulating factor (G-CSF) was found to improve the event-free survival of localized ES [4] compared to VDC/IE scheduled every 21 days.