In this study, we screened six factors including age > 65 years, LDH > 250 U/L, CsCa > 2.75 mmol/L, BNP or NT-proBNP > 2 ULN, high-risk cytogenetics, and Barthel index score, which were independent risk factors for UHR MM. This evidence concerns the gene NPPB and Miyoshi myopathy.