No statistically significant differences were observed between the group undergoing DEB-TACE with distal radial access and the group undergoing DEB-TACE with femoral access in terms of age, gender, BMI, prothrombin time, alpha-fetoprotein, cirrhosis, Child–Pugh class, platelet count, number of tumors, maximum tumor size, technical success, conversion rate, chemoembolization patter, procedure duration, vascular access-site complications, and post-procedural clinical complications. This evidence concerns the gene F2 and neoplasm.