KLK3 and posterior cortical atrophy: Table 2 shows the current recommendations of widely used guidelines: EAU, AUA, NICE, and NCCN [59,60,61,62]. Guidelines use PSA, ISUP grade group (i.e., the updated Gleason grading system [63]; [GG]), clinical T-stage, PSA density, and tumour volume for patient selection. The stratification of newly diagnosed PCa in these guidelines is more or less based on the original D’Amico risk classification [18], but the definitions of favourable intermediate-risk (GG2) vary between the guidelines.