Second, although the main validation of SCOPE in patients with COVID-19 used four parameters (CRP, ferritin, D-dimers, and IL-6), since in our department, a regular measurement of IL-6 was not performed, we opted to use the modified SCOPE index, using the three remaining parameters, which have been found to also be predictors of outcome in COVID-19 patients [9]. The gene discussed is IL6; the disease is COVID-19.