CRP and respiratory failure: Furthermore, during the randomized control phase 3, SAVE MORE trial, a composite score, named SCOPE (the Severe Covid Prediction Estimate), which included four different biomarkers of systemic inflammation, endothelial activation, and coagulopathy (CRP, D-dimers, IL-6 and ferritin), has been proved useful in predicting progression to respiratory failure or death among patients admitted to the hospital due to COVID-19 pneumonia [9,16].