Following the study conducted by Vanarsa K et al. [28] that showed excellent performance of urinary ANGPTL-4 in the diagnosis of lupus nephritis, with an AUC of 0.96 and a specificity of 87.5%, our study also showed a subsequent increase in the AUC from the microalbuminuria to the macroalbuminuria group, and the best performance was found in the macroalbuminuria group with 2794 as the optimal cutoff value and a 97.8% specificity. This evidence concerns the gene ANGPTL4 and lupus nephritis.