β-glucans as integral components of most fungi cell walls in human fungal pathogens, are also key pathogen-associated molecular patterns (PAMPs) that elicit host immunity upon fungal infection by stimulating innate immune cells including macrophages, neutrophils, monocytes, natural killer cells (NK cells), dendritic cells (DCs), T cells, as well as granulocytes by binding to different Pattern Recognition Receptors (PRRs) such as Dectin-1, complement receptor 3 (CR3), and Toll-like receptor 2/6(TLR2/6)[5,6,7,8]. The gene discussed is TLR2; the disease is fungal infectious disease.