Moreover, PBMCs from individuals cured of PCM, stimulated ex vivo with the P. brasiliensis gp43 protein, produced increased levels of IL-2, IFNγ and IL-10; however, PBMCs from patients with active PCM (chronic or acute form) produced low levels of IL-2 and IFNγ with substantial amounts of IL-10 in response to stimulation with gp43 [21]. This evidence concerns the gene IFNG and paracoccidioidomycosis.