TNF and paracoccidioidomycosis: In this sense, it was shown that the presence of the A allele (genotypes A/A and G/A) in the promoter region of the TNF gene (−308 G/A) and IL10 gene (−1082 G/A) as well as the presence of the C allele (−590 C/T) in the IL4 gene promoter were related to increased production of these cytokines by PBMCs from patients with PCM [23,24].