A study by Doll et al. demonstrated that knockout of FSP1 increased the sensitivity of melanoma (MDA-MD-435S), colorectal cancer (SW620), glioblastoma (U-373), lung cancer (A549 and NCI-H1437) and breast cancer (MDA-MB-436) cells to RSL3 [51]. This evidence concerns the gene AIFM2 and breast carcinoma.