Molecular pathways such as the inhibition of NF-κB phosphorylation and NF-κB nuclear translocation, upregulation of TGF-β, TLR-4, TNF-α, ZO-1, GLP-2, and TGF-β1 by phytoconstituents can reduce AGEs and hyperglycemia-related complications. Here, TJP1 is linked to Hyperglycemia.