Therefore, this TDP-43-mediated degradation of Pr55Gag (Figure 2) could account for the inhibition of viral particle production observed under this experimental condition (Figure 3A, HIV-1 viral production histogram), whereas the clearance of Vif (Figure 2) could negatively affect the infectious capacity of produced HIV-1 virions (Figure 3A, data on the HIV-1 infection capacity histogram), as previously reported for HDAC6 [21,22]. The gene discussed is TARDBP; the disease is HIV-1 infection.