However, since CD8+ T cells play a crucial role in inducing viral clearance and data indicate that HBsAg clearance does not determine the recovery of an effective T cell response [32,52], treatment with anti-HBsAg monoclonal antibodies may only be able to reduce the cccDNA pool, without improving HBV-specific CD8+ T cell responses and favoring definitive recovery from infection [36,130]. Here, CD8A is linked to infection.