However, Péneau et al. [98] analyzed the characteristics of the HBV integrations involved in hepatocarcinogenesis, showing that, in HCC tumor cells, the genomic integration occurs more frequently at the level of three specific genes: telomerase reverse transcriptase (TERT), cyclin E1 (CCNE1), and KMT2B. This evidence concerns the gene CCNE1 and hepatocellular carcinoma.