The binding of IFN-γ to INF-γ receptors on tumor cell membranes activates Janus Kinase 1 (JAK1) and JAK2, which are signal transducers and activators of transcription (STAT) signaling that promote the expression of IFN-related genes, including interferon regulatory factor 1 (IRF1). The gene discussed is SOAT1; the disease is neoplasm.