Moreover, PDE-opathies name has been coined to identify a set of disorders caused by germline mutations of PDEs [205], it would be interesting to extend this concept to testicular cancers with a more focused screening since their pharmacological inhibition has been proposed as an anticancer strategy in several tumors [18], but we are still far from the “they lived happily ever after”. This evidence concerns the gene ALDH7A1 and testicular cancer.