Finkelstein, Rubin, Johnston et al. irradiated mice with doses in the range where development of pulmonary fibrosis is expected, and did indeed observe changes in TGF-β3 expression time points long before pathological changes can be observed, supporting the claim that such changes precede the development of fibrosis [109,110,111]. The gene discussed is TGFB3; the disease is pulmonary fibrosis.