CD68+ and CD163+ macrophage cells were significantly increased only in lipedema (CD68: C = 27.09 ± 35.305 cells/field, L = 42.48 ± 8.662 cells/field, LE = 26.68 ± 9.210 cells/field and H = 27.29 ± 7.543 cells/field; CD163: C = 81.18 ± 19.04 cells/field, L = 104.5 ± 15.29 cells/field, LE = 64.03 ± 25.32 cells/field, H = 75.67 ± 22.28 cells/field) (Figure 4E–H). This evidence concerns the gene CD163 and Lipedema.