Considering the important role of hydroxyprostaglandin dehydrogenase 15-(NAD) (15-PGDH) as an antagonist of COX-2 during CRC carcinogenesis, Fink and others hypothesized that susceptibility to aspirin might differ according to 15-PGDH expression levels in the colon mucosa [85]. This evidence concerns the gene HPGD and colorectal carcinoma.