In particular, three phenotypes describing the intratumor immune response have been described: “inflammatory”, with infiltrations of CD4 and CD8 lymphocytes and an overexpression of the checkpoint inhibitor PD-L1 on tumor cells; “excluded”, with the presence of immune cells but limited to the stroma and not penetrating the tumor; “immune desert”, with the absence of T cells [38]. The gene discussed is CD8A; the disease is neoplasm.