One pathway that appears to be strongly involved in DCI is the type I interferon pathway, which is involved in the secretion of cytokines and immunomodulatory chemokines (CXCL9, CXCL10) that bind to the CXCR3 receptor and in the recruitment of CD8+ T cells to the tumor microenvironment [151]. The gene discussed is CD8A; the disease is neoplasm.