GJA1 and heart failure: Indeed, evidence shows that statins could increase myocardial Cx43 expression, which is downregulated in certain pathological conditions, such as hypertriglyceridemia, acute myocardial infarction, viral myocarditis, or diabetes [13,42,43]; suppress GJ remodeling and correct the disordered distribution of connexins typical of heart failure [13,44,45]; and modulate the phosphorylation of the connexins, which is related to their internalization and degradation [13].