In addition to the effects of antioxidant micronutrients, SeP has been shown to inhibit vascular endothelial growth factor-stimulated cell proliferation, tubule formation, and migration in human umbilical vein endothelial cells [41], indicating that SeP may directly affect the induction of neoangiogenesis in ROP and represent a therapeutic target. This evidence concerns the gene VEGFA and retinopathy of prematurity.