APOE and HIV infectious disease: The lack of differences in the levels of HDL-C and LDL-C cholesterol levels between apoE−/− mice treated with HIVposEVs and controls (Supplemental Figure S1) provide further support for lin− BMC and vascular cell senescence and apoptosis as possible mechanisms, instead of cholesterol levels, that underlie the effects of HIV infection-specific factors on CVD mediated by HIVposEVs.