APOE and atherosclerosis: The observed differences in atherosclerosis burden between HIVposEVs -and HIVnegEVs-treated apoE−/− mice, together with the lack of differences in atherosclerosis burden between HIV PLdepEVs- and PBS-treated apoE−/− mice, suggest that EVs, rather than other factors in the plasma such as lipid proteins, serve as the primary carriers for the atherogenic signals associated with HIV infection.