Th2 is the most important immunological factor contributing to inflammation in children with AD; the levels of Th2 cytokines and related chemokines (e.g., IL-13, OX40 ligand, and thymic stromal lymphopoietin (TSLP) receptor) were similar or greater in lesional and nonlesional pediatric AD skin compared with those in adults [7]. The gene discussed is TNFSF4; the disease is Alzheimer disease.