RAC1 and neoplasm: Interestingly, in the tumor xenograft of this last case, mutations in the GNAQ exon 4: c.548G>A;p.(Arg183Gln)(R183Q) (VAF: 13.3% of 493 readings), RAC1 exon 3:c.161G>A;p.(Gly54Asp)(G54D) (VAF:18.2% of 623 readings) and SF3B1 exon 15: c.2206C>T;p.(Arg736Cys)(R736C) (VAF:13.3% of 1000 readings) genes were identified.