MYD88 and channelopathy: Accordingly, Piezo2 channelopathy, which has been suggested to be associated with IL-6 increases through the Hsp70/TLR4/Myd88/IL-6 pathway, as in DOMS [31], could lead to an imbalanced ratio of Th17/Treg in RA, therefore paving the way to the autoimmune response.