It has been demonstrated in another autoimmune disease that Hsp70 overly activates dendritic cells at the beginning phase of the disease [25] and induces excessive TNF-α and Interleukin-17 (IL-17) release from these dendritic cells, with TLR4/nuclear factor-kappa B (NF-κB) pathway participation [8,26,27,28,29]. The gene discussed is TLR4; the disease is autoimmune disease.