SERPINE1 and neoplasm: For example, lncNKX2–1 from gastric cancer was reported to increase tumor growth and angiogenesis in both in vitro and in vivo models to direct sponge miR-145–5p, which upregulates Serpin Family E member 1 (SERPINE1) and vascular endothelial growth factor receptor (VEGFR) 2 signaling pathways [112].